|
YEL
|
Yellow
Fever
|
|
HEP
A
|
Hepatitis
A
|
|
TYP
|
Typhoid
|
|
TET
|
Tetanus
|
|
POL
|
Polio
|
|
MEN
|
Meningitis
|
|
ENC
|
Encephalitis
B
|
|
DIP
|
Diphtheria |
|
RAB
|
Rabies
|
|
HEP
B
|
Hepatitis
B
|
|
|
M
|
Vaccination
is mandatory and a certificate
of vaccination is required for
entry.
|
|
C
|
A
certificate of vaccination may
be required if entering from an
endemic country, (except for children
<1 year old). |
|
R
|
Vaccination
is recommended for the country
but no evidence is required
for entry.
|
|
L
|
Long
Term. Vaccination recommended
for travellers staying in endemic
areas for 3 months or more.
|
| |
| |
|
Countries
requiring malaria prophyllaxis
should be regarded as being at risk
all year round and you should
also assume that the whole country
is at risk unless otherwise indicated.
The 1st malaria regimen (MAL
1) is the preferred regimen
for a country. The 2nd malaria
regimen (MAL 2) is an alternative
that should only be used when the
1st Regimen is either unavailable
or badly tolerated. The preferred
regimen should always be used whenever
possible. Use of the 2nd regimen in
some instances may not provide adequate
cover.
When
there are two different regimens
for the same country, they are area
specific. Read the text to find out
which regimen is suitable for the
area you require.
Where regimen 1 is indicated
there is Chloroquine resistance in
that region and it is very likely
to be the Falciparum malaria which
is the most serious form of the disease.
In this instance it is vitally important
that travellers take adequate prophylaxis.
Remember:- No prophylaxis is
100% effective but not taking anti-malarials
where they are indicated will put
you at greater risk should you get
the disease. Malaria is a killer!
| |
| |
|
The
Different Drug Regimens
|
| Regimen
1 |
Mefloquine
one 250mg tablet weekly.
OR
Doxycycline one 100mg capsule daily.
OR
Malarone one tablet daily. |
| Regimen
2 |
Chloroquine
300mg
weekly
(2x150mg tablets).
PLUS
Proguanil 200mg
daily
(2x100mg tablets). |
| Regimen
3 |
Chloroquine
300mg
weekly
(2x150mg tablets) OR
Proguanil 200mg daily
(2x100mg tablets). |
| Regimen
4 |
No
prophylactic tablets required but
anti mosquito measures such as insect
repellents, mosquito nets, long sleeved
clothing, etc. should be strictly observed. |
| . |
|
| |
| Proguanil
|
100mg
tablets are supplied as Paludrine
Tablets |
| Chloroquine
|
150mg
tablets are supplied as Nivaquine
or Avloclor Tablets |
| Mefloquine
|
250mg
tablets are supplied as Lariam
Tablets |
| Malarone
|
is
a combination of Atovaquone 250mg
and Proguanil 100mg |
|
| |
|
Length
of Prophylaxis
|
| Chloroquine,
Proguanil & Maloprim |
Start
one week before travel, throughout
your stay in an endemic area and continue
for four weeks after return. |
| Mefloquine
(Lariam) |
Start
two and a half weeks before travel,
throughout your stay in an endemic area
and continue for four weeks after
return. |
| Doxycycline |
Start
two days before travel, throughout
your stay in an endemic area and continue
for four weeks after return. |
| Malarone |
Start
two days before travel, throughout
your stay in an endemic area and continue
for one week after return. |
|
IMPORTANT!
Take
the tablets absolutely regularly,
preferably with or after a meal.
|
|
| |
|
Long
Term Use of Anti-Malaria Drugs
|
| Chloroquine |
May
be taken for periods exceeding five
years. |
| Paludrine |
May
be taken for periods exceeding five
years. |
| Maloprim |
Can
be taken for periods up to one year. |
| Mefloquine |
Can
be taken for periods up to one year. |
| Doxycycline |
Can
be taken for periods up to six months. |
| Malarone |
Can
be used for travel periods up to three
months. |
|
| |
|
Compatibility
of Anti-Malaria Drugs
|
| |
Pregnancy
|
Breast
Feeding
|
Epilepsy
|
Psoriasis
|
Altitude
|
Scuba
Diving
|
| Chloroquine |
OK
|
OK
|
NO
|
NO
|
OK
|
OK
|
| Paludrine |
OK
|
OK
|
OK
|
OK
|
OK
|
OK
|
| Mefloquine
|
OK*
|
NO
|
NO
|
OK
|
NO
|
NO
|
| Doxycycline |
NO
|
NO
|
OK
|
OK
|
OK
|
OK
|
| Malarone |
NO
|
NO
|
OK
|
OK
|
OK
|
OK
|
|
*
These drugs are not suitable during
the first trimester of pregnancy.
|
|
| |
|
Childrens'
Dosages:
Calculate
the dose by weight rather than by
age if possible
|
|
Age/Weight
|
Chloroquine
(once weekly)
|
Proguanil
(once daily)
|
Mefloquine
(once weekly)
|
Doxycycline
(once daily)
|
Malarone
(once daily)
|
|
0
- 12 weeks
under 6kg
|
¼
tablet
|
¼
tablet
|
-
|
-
|
-
|
|
3
- 12 months
6 - 10kg
|
½
tablet
|
½
tablet
|
¼
tablet
|
-
|
-
|
|
1
- 3 years
10 - 16kg
|
¾
tablet
|
¾
tablet
|
¼
tablet
|
-
|
1
child's
tablet
|
|
4
- 7 years
16 - 25kg
|
1
tablet
|
1
tablet
|
½
tablet
|
-
|
1
child's
tablet
|
|
8
- 12 years
25 - 45 Kg
|
1½
tablets
|
1½
tablets
|
¾
tablet
|
-
|
2
child's
tablets
|
|
13
years and over
45kg and over
|
2
tablets
|
2
tablets
|
1
tablet
|
1
capsule
|
1
adult
tablet
|
|
The
above dosages are based upon the guidelines
issued by
the Advisory Committee on Malaria
Prevention.
|
|
| |
|
Adult
Dosages
|
|
Regimen
|
Dose
for
Chemoprophylaxis
|
Usual
amount
per tablet (mg)
|
| Areas
without drug resistance: |
|
Chloroquine
Proguanil
|
2
tablets weekly
2
tablets daily
|
150mg
(base)
100mg
|
| Areas
of little chloroquine resistance (poorly
effective where marked resistance): |
Chloroquine
plus
Proguanil |
2
tablets weekly
2 tablets daily |
150mg
(base)
100mg |
| Areas
of chloroquine resistant P. falciparum: |
|
Mefloquine
Doxycycline
Malarone
(atovaquone & proguanil)
|
1
tablet weekly
1
tablet/capsule daily
1
tablet daily
|
250mg
(228 in USA)
100mg
250mg
atovaquone &
100mg proguanil
|
|
| |